Molecular architecture of the mammalian circadian clock
نویسندگان
چکیده
منابع مشابه
Molecular architecture of the mammalian circadian clock.
Circadian clocks coordinate physiology and behavior with the 24h solar day to provide temporal homeostasis with the external environment. The molecular clocks that drive these intrinsic rhythmic changes are based on interlocked transcription/translation feedback loops that integrate with diverse environmental and metabolic stimuli to generate internal 24h timing. In this review we highlight rec...
متن کاملMolecular components of the Mammalian circadian clock.
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in the environment. This is achieved by ocular photoreception relaying signals to the suprachiasmatic nucleus (SCN) in the hypothalamus. Signals from the SCN cause the synchronization of independent circadian clocks throughout the body to appropriate phases. Signals that can entrain these peripheral clock...
متن کاملMolecular signals of Mammalian circadian clock.
The circadian rhythm is originally generated by a transcription-translation based oscillatory loop composed of a set of clock genes in most organisms. The clock gene oscillation is generated by the core loop in each neuron of the hypothalamic suprachiasmatic nucleus. Phosphorylation and ubiquitination of clock proteins play the crucial role for the rhythmic transcription of clock genes. The cor...
متن کاملThe mammalian circadian clock.
Organisms populating the earth are under the steady influence of daily and seasonal changes resulting from the planet's rotation and orbit around the sun. This periodic pattern most prominently manifested by the light-dark cycle has led to the establishment of endogenous circadian timing systems that synchronize biological functions to the environment. The mammalian circadian system is composed...
متن کاملNetwork Features of the Mammalian Circadian Clock
The mammalian circadian clock is a cell-autonomous system that drives oscillations in behavior and physiology in anticipation of daily environmental change. To assess the robustness of a human molecular clock, we systematically depleted known clock components and observed that circadian oscillations are maintained over a wide range of disruptions. We developed a novel strategy termed Gene Dosag...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2014
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2013.07.002